image: Voxelwise Ktrans maps. Representative voxelwise BBB Ktrans maps in 2 OA (top) and 2 YA (bottom) participants classified as having high and low BBBd. Color bar shows absolute Ktrans values with units of min-1.
Credit: Denkinger et al., 2024, PLOS ONE, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)
Normal ageing might be associated with increased blood-brain barrier permeability in regions also vulnerable in Alzheimer's Disease, in small study comparing healthy brains of the young and old
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Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0299764
Article Title: Associations between regional blood-brain barrier permeability, aging, and Alzheimer’s disease biomarkers in cognitively normal older adults
Author Countries: USA
Funding: Research reported in this publication was supported by the National Institute On Aging of the National Institutes of Health under Award Number F31AG072872 and R01 AG080043. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Journal
PLOS ONE
Article Title
Associations between regional blood-brain barrier permeability, aging, and Alzheimer’s disease biomarkers in cognitively normal older adults
Article Publication Date
5-Jun-2024
COI Statement
I have read the journal’s policy and the authors of this manuscript have the following competing interests: Dr. Jagust has served as a consultant to Clario, Lilly and Eisai. Dr. Baker consults for Genentech. There are no other disclosures. This does not alter our adherence to PLOS ONE policies on sharing data and materials.