https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/14/issue/1
Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Articles of interest in this issue include:
Targeting stroma and tumor, silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma by Tahereh Setayesh et al. (https://doi.org/10.1016/j.apsb.2023.10.010). Targeting Gal1 is effective in preventing as well as treatment of HCC and has translational potential.
High-throughput screening of novel TFEB agonists in protecting against acetaminophen-induced liver injury in mice by Xiaojuan Chao et al. (https://doi.org/10.1016/j.apsb.2023.10.017). Genetic and pharmacological activation of TFEB increases lysosomal biogenesis that promotes clearance of acetaminophen adducts resulting in protection against AILI. qHTS is a very useful platform to identify novel mTOR-dependent and independent TFEB agonists that may have translational therapeutic value for targeting drug-induced liver injury.
Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling by Yong Rao et al. (https://doi.org/10.1016/j.apsb.2023.08.032). The identified marine fungus metabolite HN-001 ameliorates lipotoxicity by suppressing IRE-1α/XBP-1s axis and JNK pathway for MAFLD treatment with PLA2 as an upstream target.
Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy by Hui Yu et al. (https://doi.org/10.1016/j.apsb.2023.08.019). The peroxynitrite upconversion nanogenerator NRh-Ph-NO nanoparticles empowered with superior mitochondrial targeting could induce reactive nitrogen species-potentiated precision gas therapy guided by frequency upconversion luminescence imaging upon 808 nm laser irradiation.
Other articles include:
Review Articles
Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba
Weile Ye, Jiaojiao Wang, Peter J. Little, Jiami Zou et al.
Effects of small molecules on neurogenesis: Neuronal proliferation and differentiation
Michał K. Jastrzębski, Piotr Wójcik, Piotr Stępnicki, Agnieszka A. Kaczor
Traditional Chinese medicine for the treatment of immune-related nephropathy: A review
Pu Jiang, Changliang Yao, De-an Guo
Chunhao Zhu, Xiaobing Lan, Zhiqiang Wei, Jianqiang Yu, Jian Zhang
Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors
Letian Song, Shenghua Gao, Bing Ye, Mianling Yang et al.
Emerging delivery systems based on aqueous two-phase systems: A review
Yaowen Zhang, Yankun Luo, Jingqi Zhao, Wenzhuo Zheng et al.
Plant-derived nanovesicles as an emerging platform for cancer therapy
Hanzhe Liu, Guo-Feng Luo, Zhengjun Shang
Honglan Wang, Yannan Liu, Changqing Bai, Sharon Shui Yee Leung
Advanced nano-based strategies for mRNA tumor vaccine
Yangqi Qu, Jingjing Xu, Tong Zhang, Qinjun Chen et al.
Original Articles
Hongrui Zhu, Yamin Gao, Liyun Liu, Mengyu Tao et al.
Lei Sun, Arabella H. Wan, Shijia Yan, Ruonian Liu et al.
Xuezhi Yang, Yingjie Zhao, Qi Wei, Xuemin Zhu et al.
Jiawen Zhou, Xinyue Sun, Xuelian Chen, Huimin Liu et al.
Duc-Vinh Pham, Thi-Kem Nguyen, Bao-Loc Nguyen, Jong-Oh Kim et al.
Structure-based development of potent and selective type-II kinase inhibitors of RIPK1
Ying Qin, Dekang Li, Chunting Qi, Huaijiang Xiang et al.
Ju Chen, Bhaskara Reddy Madina, Elham Ahmadi, Timur Olegovich Yarovinsky et al.
Yongshun Zhang, Lan Yang, Yangsen Ou, Rui Hu et al.
Dandan Ling, Xueli Jia, Ke Wang, Qiucheng Yan et al.
Visualization of nasal powder distribution using biomimetic human nasal cavity model
Jiawen Su, Yan Liu, Hongyu Sun, Abid Naeem et al.
Ruibing Chen, Jian Yu, Luyao Yu, Liang Xiao et al.
Dexiu Yan, Jemma Arakelyan, Teng Wan, Ritvik Raina et al.
Commentary
Commentary: Gut microbiota reduce the risk of hyperuricemia and gout in the human body
Lin Wang, Jianping Ye
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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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CiteScore: 15.9
Impact Factor: 14.907
JIF without self-citation: 13.885
ISSN 2211-3835
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