https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/13/issue/12

Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.

APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.

Articles of interest in this issue include:

 

Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma by Yingqiang Liu, Zhengsheng Zhan, Zhuang Kang et al. (https://doi.org/10.1016/j.apsb.2023.09.009). SYHA1813 exerts anti-tumor effects by simultaneously inhibiting angiogenesis and affecting tumor-associated macrophages, and shows the therapeutic potential of glioma by efficiently crossing the blood–brain barrier.

 

Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection by Xintong Zhao, Jing Feng, Jie Zhang et al. (https://doi.org/10.1016/j.apsb.2023.08.030). A novel pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection with excellent pharmacological activity and druggability was discovered by the structural modifications of the AZD5099 which was withdrawn from clinical trials.

 

Hippo pathway-manipulating neutrophil-mimic hybrid nanoparticles for cardiac ischemic injury via modulation of local immunity and cardiac regeneration by Qiaozi Wang, Yanan Song, Jinfeng Gao et al. (https://doi.org/10.1016/j.apsb.2023.08.021). Hybrid neutrophil-mimic nanoparticle NM@miR could realize absorption of proinflammatory cytokines and delivery of proliferative microRNA together, which holds huge potential for the regenerative treatment of cardiac ischemic diseases.

 

Other articles include:

 

Review Articles

Targeting the blood–brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays

Yanping Wang, Weihong Du, Xiaoyan Hu, Xin Yu, ... Wei Wang

 

Targeting autophagy and beyond: Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy

Jing Ye, Jin Zhang, Yanghui Zhu, Lian Wang, ... Gu He

 

Emerging drug design strategies in anti-influenza drug discovery

Chuanfeng Liu, Lide Hu, Guanyu Dong, Ying Zhang, ... Peng Zhan

 

 

 

Original Articles

ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells

Mingjin Wang, Weida Wang, Shen You, Zhenyan Hou, ... Jing Jin

Non-canonical STING–PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response

Xuesong Li, Xiang Chen, Longbin Zheng, Minghong Chen, ... Hongshan Chen

Macrophage LMO7 deficiency facilitates inflammatory injury via metabolic-epigenetic reprogramming

Shixin Duan, Xinyi Lou, Shiyi Chen, Hongchao Jiang, ... Feng

Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner

Kaikai Zhang, Lijian Chen, Jianzheng Yang, Jiali Liu, ... Qi Wang

TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage

Wenjun Yu, Haixia Xu, Zhe Sun, Yuxin Du, ... Yingmei Zhang

ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17

Junting Zhang, Yiying Li, Jianchao Zhang, Lu Liu, ... Xiaowei Nie

Immunogenicity of mucosal COVID-19 vaccine candidates based on the highly attenuated vesicular stomatitis virus vector (VSV_MT) in golden syrian hamster

Yong Ke, En Zhang, Jianming Guo, Xiaoxiao Zhang, ... Baohong Zhang

Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis

Wenjing Yu, Yuehuai Hu, Zhiping Liu, Kaiteng Guo, ... Jing Lu

A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors

Youchao Deng, Xiaosheng Song, Iredia D. Iyamu, Aiping Dong, ... Rong Huang

Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility

Li-Min Zhao, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen

Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors

Feifei Fang, Yang Dai, Hao Wang, Yinchun Ji, ... Yu Zhou

Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer

Jia-Luo Huang, Xue-Long Yan, Dong Huang, Lu Gan, ... Sheng Yin

Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer

Yubo Wang, Jian Min, Xiangping Deng, Tian Feng, ... Hai-Bing Zhou

Development of exosome membrane materials-fused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent

Yongho Jang, Jeehun Park, Pilsu Kim, Eun-Joo Park, ... Hyuncheol Kim

Reactive oxygen species and nitric oxide scavenging nanoparticles alleviating rheumatoid arthritis through adjusting the seeds and growing soils

Peng Hua, Ruifeng Liang, Yanbei Tu, Yuying Yin, ... Meiwan Chen

Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity

Huaqing Jing, Yingzi Ren, Yue Zhou, Min Xu, ... Nan Li

Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy

Xiaodi Liu, Qi Zhang, Yixia Liang, Shiyu Xiong, ... Baoming Luo

Purpurolide C-based microneedle promotes macrophage-mediated diabetic wound healing via inhibiting TLR4-MD2 dimerization and MYD88 phosphorylation

Yitong Liu, Guiyang Xia, Yingyi Chen, Huan Xia, ... Yi Liu

Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy

Lina Guo, Jinsong Ding, Wenhu Zhou

An injectable signal-amplifying device elicits a specific immune response against malignant glioblastoma

Qiujun Qiu, Sunhui Chen, Huining He, Jixiang Chen, ... Jianxin Wang

Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment

Yan Zhang, Haiyun Zhang, Faquan Zhao, Zhengping Jiang, ... Qiangsong Wang

Orange-derived extracellular vesicles nanodrugs for efficient treatment of ovarian cancer assisted by transcytosis effect

Feng Long, Yao Pan, Jinheng Li, Suinan Sha, ... Ying Wang

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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

 

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

 

Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).

 

CiteScore: 15.9

Impact Factor: 14.907

JIF without self-citation: 13.885

 

ISSN 2211-3835

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