Two methods used to determine mutation rate in whales (IMAGE)
Caption
Nuclear mutation rates were determined through genome sequencing of whale trios (mother, father, and calf). The mutation rate was calculated by counting nucleotide base changes (i.e. mutations) exclusive to the calf and dividing them by the total number of bases. The mitochondrial mutation rate was estimated by analyzing the transmission of mitochondrial heteroplasmy (two distinct mitochondrial genomes within an individual caused by a mutation) and its frequency across hundreds of maternal lineages.
Credit
Marcos Suárez-Menéndez, University of Groningen
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License
CC BY-SA