Increased FA connections and networks in ASD compared to TD children. (IMAGE)
Caption
Increased FA connections and networks in ASD compared to TD children. (A) The 33 increased FA values of structural connections in ASD in circos plot. Abbreviations: L, left hemisphere; R, right hemisphere; FRO, frontal lobe; TEM, temporal lobe; PAR, parietal lobe; INS, insular lobe; LIM, limbic lobe; OCC, occipital lobe; SUB, subcortical nuclei; CERE, cerebellum; BS, brain stem. (B) Locations of 33 connections on the cortical surface. (C) Averaged FA value of 33 connections in ASD and TD groups. (D) Correlations between averaged FA value of the 33 connections in ASD and ADOS ‘social interaction’ sub-scale score and total (‘communication’ + ‘social interaction’) score. (E) Correlations between averaged FA value of the 33 connections and ADOS social communication and total scores and GDS total score. (F) Mediation analysis between averaged FA, GDS total score and ADOS total score (path a = −0.27, P = 0.018; path b = −0.66, P < 0.001; path c = 0.22, P = 0.047; path c’ = 0.049, P = 0.58). ( G) The 33 increased connections were further categorized into 5 structural networks. In each network, row 1–3 shows the structural connections in circos plot, locations of the connections on cortical surface, and the word cloud of functional annotation via meta-analysis respectively.
Credit
Psychoradiology
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