Somatostatin dampens cortical signaling (IMAGE)
Caption
Activity of pyramidal neurons in the prefrontal cortex before (left) and after (right) application of somatostatin. Inhibitory neurons (pink) release somatostatin, a neuropeptide, that binds to receptors on the surface of pyramidal neurons (purple) and other cells in the brain. Representative traces from whole-cell current clamp recordings (black lines) show that the activity of pyramidal cells is reduced following both bath applied somatostatin, and light-evoked somatostatin release.
Credit
Crowley Laboratory/Penn State
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