Kidney sodium magnetic resonance images of m+/m+ (BKS.Cg-m+/m+/Jcl) and db/db mice (BKS.Cg-Leprdb+/+ Leprdb/Jcl) (N=7 each). (IMAGE)

Niigata University

Kidney sodium magnetic resonance images of m+/m+ (BKS.Cg-m+/m+/Jcl) and db/db mice (BKS.Cg-Leprdb+/+ Leprdb/Jcl) (N=7 each).

Caption

(A, B) 23Na MR image merged with 1H MR image of the right kidney in an m+/m+ mouse (A) and a db/db mouse (B). (C) The signal intensity gradients from the cortex to the medulla in m+/m+ and db/db mice. The signal intensity of the medullary region in the kidney was lower in db/db mice than in m+/m+ mice. The sodium concentration gradients from the medulla to the cortex of m+/m+ and db/db mice were 2.28±0.21 and 1.64±0.36, respectively (P < 0.01). Nakagawa, Yusuke; Kaseda, Ryohei; Suzuki, Yuya; Watanabe, Hirofumi; Otsuka, Tadashi; Yamamoto, Suguru; Kaneko, Yoshikatsu; Goto, Shin; Terada, Yasuhiko; Haishi, Tomoyuki; Sasaki, Susumu; Narita, Ichiei. Sodium Magnetic Resonance Imaging Shows Impairment of the Counter-current Multiplication System in Diabetic Mice Kidney. Kidney360 4(5):p 582-590, May 2023. | DOI: 10.34067/KID.0000000000000072

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