(IMAGE)

Tokyo Medical and Dental University

Caption

In normal conditions, active FAK acts as a component of focal adhesions. Upon genotoxic stress, however, Nrf2 drives the expression of the Frnk gene, whereas active FAK is reduced via lysosomal degradation. This results in FAK/FRNK replacement in focal adhesions, and this remodelling counteracts genotoxic stress in normal as well as pathological tissues by enhancing cell adhesion.

Credit

Department of Pathological Cell Biology, TMDU

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