Model showing the responses of focal adhesions to genotoxic stress (IMAGE)

Tokyo Medical and Dental University

Model showing the responses of focal adhesions to genotoxic stress

Caption

In normal conditions, active FAK acts as a component of focal adhesions. Upon genotoxic stress, however, Nrf2 drives the expression of the Frnk gene, whereas active FAK is reduced via lysosomal degradation. This results in FAK/FRNK replacement in focal adhesions, and this remodelling counteracts genotoxic stress in normal as well as pathological tissues by enhancing cell adhesion.

Credit

Department of Pathological Cell Biology, TMDU

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