Fig. 2. Cortical functional network abnormalities in a mouse model of autism (IMAGE)

Kobe University

Fig. 2. Cortical functional network abnormalities in a mouse model of autism

Caption

A, Representative trajectory (left) and locomotion behavior (right) for Emx1G6 mice and Emx1G615q dup mice. Locomotion speed and periods of locomotion (Loco) and rest of each genotype are shown from top to bottom in the right panel. B, Locomotor activity of Emx1G6 mice and Emx1G615q dup mice during 10-min sessions. Data represent mean ± SEM. P-value by t-test. n = 89 sessions from 7 Emx1G6 mice and 88 sessions from 9 Emx1G615q dup mice. C, Percentages of time spent for each type of episode in Emx1G6 mice and Emx1G615q dup mice. Data represent averages across all sessions. D-E, Changes in cortical functional network dynamics near the locomotion start and stop points in wild-type (D) and 15q dup mice (E). F, The average number of functional connections that each region of interest has before and after the behavior change point. G, Mean value of network centrality for each region of interest. H, Comparison of Modularity.

Credit

Nakai, N., Sato, M., Yamashita, O. et al. Virtual reality-based real-time imaging reveals abnormal cortical dynamics during behavioral transitions in a mouse model of autism. Cell Reports (2023). DOI：10.1016/j.celrep.2023.112258

Usage Restrictions

Please credit

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.