End-stabilization by CAMSAP3 (IMAGE)

School of Science, The University of Tokyo

End-stabilization by CAMSAP3

Caption

A CAMSAP3 molecule is first recruited to the microtubule end via an “end-detector” region in the protein, and then, D2 expands the microtubule. The expanded microtubule region promotes further CAMSAP3 binding as D2 can both detect and attach to the expanded microtubules. The positive feedback loop leads to the accumulation of CAMSAP3 around the microtubule ends.

Credit

Liu and Shima et al 2023

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License

CC BY

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