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The conventional equation recommended by the FDA guidance (upper) and the newly derived equation (lower) for predicting drug-drug interaction. The FDA guidance has recommended the upper equation for predicting the drug-drug interaction mediated by enzyme induction. However, due to its low accuracy, artificial constants have been used to calibrate the equation. To address this issue, the scientists identified the major cause of the inaccuracy of the conventional equation and derived a new equation based on rigorous mathematical theory.
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Institute for Basic Science
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