Figure 2 (IMAGE)

Institute for Basic Science

Figure 2

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The new equation provides more accurate predictions than the conventional FDA equation. The FDA equation with Fg estimated assuming Fa = 1 underpredicts the area under the curve ratio (AUCR), which represents the drug-drug interaction mediated by CYP enzyme induction, for numerous drug pairs (grey dots). On the other hand, the new equation with re-estimated Fg predicts the AUCR within two-fold errors for nearly double the number of drug pairs than the conventional FDA equation. Solid and dashed lines are the line of precise prediction and two-fold error, respectively.

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