Proposed strategy for FuOXP-mediated immunosuppression and effect of Xkr8 siRNA (IMAGE)
Caption
Proposed strategy for how chemotherapy FuOXP can lead to immunosuppression (left side of image) in tumors but a novel immunotherapy that blocks expression of a protein called Xkr8 can reactivate the immune system (right side of image). The new study found that FuOXP led to increased levels of Xkr8, a protein that redistributes PS to the cell surface, resulting in immunosuppression due to more T regulatory cells and tumor-promoting M2 macrophages. However, when the researchers blocked expression of Xkr8 with siRNA, PS remained within the cell membrane’s inner layer, enhancing the immune system by boosting numbers of tumor-fighting T cells, M1 macrophages and dendritic cells.
Credit
Chen et al., 2022, Nature Nanotechnology, 10.1038/s41565-022-01266-2
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