Fig. 2 (IMAGE)

Osaka University

Fig. 2

Caption

Dialysis-related amyloidosis is caused by the deposition of beta2-microglobulin amyloids. The white deposits on the wrist tendon in the picture are mainly composed of beta2-microglobulin amyloids. Previous research into dialysis-related amyloidosis has shown that the primary and secondary risk factors for this disease are an aberrant increase in blood beta2-microglobulin concentration and a long dialysis vintage. However, not all patients with these risk factors develop dialysis-related amyloidosis, implying that there are other, unknown, risk factors that should be identified to help prevent the development of dialysis-related amyloidosis. Professor Fumitake Gejyo (co-author of this study) of Niigata university was the first to report that beta2-microglobulin aggregation is causative for dialysis-related amyloidosis [Gejyo et al., Biochem. Biophys. Res. Commun. 129, 701-706 (1985)]. As of 2022, one out of 380 Japanese citizens receive dialysis treatment. In patients who started dialysis treatment in 2010 cohort, who have a dialysis vintage of more than 20 years, the risk of developing dialysis-related amyloidosis is 10% [Hoshino et al., Nephrol. Dial. Transplant. 31, 595-602 (2016)].

Credit

1. F. Gejyo et al., N. Engl. J. Med. 314, 585-586 (1986). 2. S. Yamamoto et al., Biochim. Biophys. Acta 1753, 4-10 (2005).

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