Fig. 2 (IMAGE)

Shinshu University

Fig. 2

Caption

In wild-type mice, cell survival is maintained by the autocrine action of neurotrophic factors released from the axons of cerebellar granule cells. In wild-type mice, neurexin binds to Cbln1-GluD2 and induces cerebellar synaptogenesis. Granule cells deficient in all neurexins 1, 2, and 3 have abnormal neurotrophic factor release mechanisms, resulting in induced programmed cell death.

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Takeshi Uemura, Shinshu University

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