CP-673451 treatment reduces the release of several cytokines and chemokines during sepsis. (IMAGE)

Science China Press

CP-673451 treatment reduces the release of several cytokines and chemokines during sepsis.

Caption

A, Serum cytokine levels of control, CLP and CP-673451-treated CLP group (CLP+CP-673451) mice were detected by cytokine array kits on the 1st and 3rd days post-sepsis. The cytokines labeled red were elevated after CLP but significantly reduced after treatment with CP-673451. The cytokines labeled blue were decreased after both CLP and treatment with CP-673451. B, CXCL13 release assayed using enzyme-linked immunosorbent assay (ELISA) from control and CLP with or without CP-673451 treatment on the 1st and 3rd days after sepsis. C, CXCL13 release assayed using ELISA in serum samples of sepsis patients and healthy volunteers. *, P<0.05; **, P<0.01. D, Serum cytokine and chemokine levels of control and CLP mice treated with or without CP-673451 were detected by Luminex liquid chip.

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