cultured mammalian cells - 3D rotation (IMAGE)
Caption
Zoom-in on single cultured mammalian cells in which TDP-43 has been induced to aggregate. In this system, the cells produce TDP-43 fused to a green fluoresce molecule, to be able to detect whether the protein forms insoluble granules (green fluorescent dots). The RNA probe is labelled with a red fluorescent tag. The yellow colour, given by the overlap between the green of TDP-43 and the red of the RNA probe, signifies that the probe can search and find its protein target in live cells, suggesting that it could be use as a detection tool to track the progress of TDP-43 aggregation in disease. Blue: nuclei; green: TDP-43; red: RNA probe; yellow: TDP-43+RNA probe.
Credit
IIT-Istituto Italiano di Tecnologia
Usage Restrictions
use with appropriate credits and caption
License
Original content