Intestinal epithelial cells serve as an integral component in the regulatory loop consisting of gut microbes and host immune cells (IMAGE)

Toho University

Intestinal epithelial cells serve as an integral component in the regulatory loop consisting of gut microbes and host immune cells

Caption

In the normal intestine, IECs control gut bacteria by releasing anti-microbial factors in response to IL-17. Because increase in SFB leads to up-regulation of IL-17 by promoting Th17 cell generation, the numbers of SFB and Th17 cells are maintained constant. In contrast, lack of IκBζ in IECs results in expansion of both SFB and Th17 cells, which can cause the development of autoimmune diseases.

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Soh Yamazaki

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