Mpro enzyme active site at different relative humidities (IMAGE)

DOE/Brookhaven National Laboratory

Mpro enzyme active site at different relative humidities

Caption

Structures of the Mpro active site taken at the same temperature (298 Kelvin, K, or ~77°F) but different conditions of relative humidity (RH). A comparison reveals one extra water molecule (H2O) near the active site under the high humidity condition (b) that was not present at ambient humidity (a). This water molecule could offer a clue where an inhibitor molecule might bind to disable the Mpro enzyme.

Credit

Brookhaven National Laboratory/CUNY

Usage Restrictions

OK for use with stories about this research

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.