Fig. 1 (IMAGE)

Osaka University

Fig. 1

Caption

We propose that malignant hyperthermia occurs when runaway thermogenesis is caused by a heat-sensitive Ca2+-release channel (RyR1). Anesthesia is known to trigger Ca2+ release through mutant RyR1 variants, facilitating thermogenesis in muscle cells (gray arrows). In the present study, we found that applying heat causes Ca2+ release through RyR1 by a mechanism that we call "Heat-Induced Ca2+ Release (HICR)" (a red arrow). This creates a positive feedback loop that accelerates progression of the disease.

Credit

2022, Kotaro Oyama et al, Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating, Proceedings of the National Academy of Sciences, U.S.A.

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