H3K27me3通过抑制UHRF1介导的H3泛素化来负调控DNA甲基化 (IMAGE)

Science China Press

H3K27me3通过抑制UHRF1介导的H3泛素化来负调控DNA甲基化

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在有（左）或没有（右）H3K27me3修饰的区域UHRF1-DNMT1介导DNA甲基化的示意图。H3K27me3抑制UHRF1介导的H3泛素化，而H3泛素化是招募和激活DNMT1所必需的。

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©《中国科学》杂志社

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