H3K27me3 antagonizes DNA methylation by inhibition of UHRF1-mediated H3 ubiquitination (IMAGE)

Science China Press

H3K27me3 antagonizes DNA methylation by inhibition of UHRF1-mediated H3 ubiquitination

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The illustration of UHRF1-DNMT1 mediated DNA methylation at a genomic region with (left) or without (right) H3K27me3 modification. The presence of H3K27me3 inhibits UHRF1 mediated H3 ubiquitination, which is required for recruitment and activation of DNMT1.

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