Mechanism of action for anticoagulant fibers and kill-switches (IMAGE)

University of North Carolina at Charlotte

Mechanism of action for anticoagulant fibers and kill-switches

Caption

(a, b) Design of anticoagulant fibers carrying NU172 and RA-36 aptamers with three possible aptamer locations within the fibers being indicated. (c) Binding of anticoagulant fibers to thrombin, preventing the blood clotting cascade. (d) Binding of kill-switches to anticoagulant fibers, causing reinstatement of thrombin function and producing smaller assemblies for accelerated renal excretion.

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UNC Charlotte

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