Fig.2 (IMAGE) Osaka University Caption Increased liver carcinogenesis by p53 activation in hepatocyte-specific Kras-mutant mice and the tumor-suppressive effect of peretinoin (4 months of age). Credit 2022 Makino Y, et al. Constitutive activation of the tumor suppressor p53 in hepatocytes paradoxically promotes non-cell autonomous liver carcinogenesis. Cancer Research Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted. License CC BY-NC-ND Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.