Figure 3. Changes in VEGF internalization after Merlin-depletion in EC and the physical interaction of Merlin, VEGFR2, and VE-cadherin depending on cell density (IMAGE)
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After Merlin inhibition in ECs, VEGF internalization at the vascular front was promoted compared with WT mice (Fig.3 A). Under dense cultured conditions (D), Merlin/VEGFR2/VE-cadherin interaction was enhanced while the complex was not associated under sparsely cultured conditions (Fig.3 B). Moreover, Merlin exclusively binds to VEGFR2 among other angiogenic receptor tyrosine kinase (Tie2, VEGFR3) (Fig.3 C).
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