Figure 2 (IMAGE) Osaka Metropolitan University Caption IGF-1 in the prefrontal cortex is essential for the antidepressant actions of ketamine. Mice where IGF-1 is neutralized by the antibody are more immobile, a sign of depression. Credit M. Kondo, OMU Usage Restrictions News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.