CGRP Graphic (IMAGE) University of California - San Diego Caption CGRP signals trigger a molecular cascade that reduces the expression of tight junction proteins, weakening the seal between endothelial cells. Credit UC San Diego Health Sciences Usage Restrictions Use credit License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.