Figure 3 (IMAGE)

Osaka University

Figure 3

Caption

(A-B) MRI images of steatotic hepatocellular carcinoma (HCC) (arrows) (A1; in-phase T1-weighted gradient-echo image showing a hyperintense mass; A2; Opposed-phase T1-weighted gradient-echo image showing decreased signal intensity of the tumor; A3; Hepatic artery phase of Gd-EOB-DTPA contrast-enhanced image showing arterial enhancement of the tumor, A4; 20-minute hepatobiliary phase of Gd-EOB-DTPA contrast-enhanced image reveals a drop in the signal intensity of the tumor); (B) hematoxylin and eosin (HE) staining images (B). (C) Histologically quantified intratumoral fat droplet content strongly correlates with fat content calculated from MRI images; (D) Progression-free survival (PFS) is significantly prolonged with atezolizumab/bevacizumab combination therapy in steatotic HCC.

Credit

2022 Hiroki Murai et al. Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma. Hepatology

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