Platform for building and modifying proteoglycans reveals more about disease (IMAGE)
Caption
Scripps Research scientists developed a method to build and test sugared proteins called proteoglycans to understand their role in health and disease. Envisioned as a factory production line, mammalian CHO-S and E. coli are fed chemical compounds to produce glycosaminoglycans and sydecan-1 core proteins. These modules are then selectively conjugated through a method called “click chemistry” (CuAAC) to complete the semi-synthetic proteoglycan, which can be attached to cell surfaces.
Credit
Meg Critcher, Scripps Research
Usage Restrictions
with credit and related coverage
License
Original content