Fig.2 Induction of lacrimal gland progenitor cells and 3D lacrimal gland organoids (IMAGE)

Osaka University

Fig.2 Induction of lacrimal gland progenitor cells and 3D lacrimal gland organoids

Caption

(A) Lacrimal gland-like cell clusters induced in zone-3 (lacrimal gland/corneal primordial region) of human iPS cell-derived eye-like organoids were isolated and cultivated in Matrigel, resulting in the formation of 3D lacrimal gland-like organoids with budding and branching. (B) Lacrimal gland organoids were generated by the 3D culture of lacrimal gland progenitor cells isolated by cell sorting. (C) 3D lacrimal gland organoids expressed lacrimal gland markers (PAX6, AQP5, SOX9).

Credit

Hayashi R. et al. Generation of 3D lacrimal gland organoids from human pluripotent stem cells. Nature 2022

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