Figure 2 (IMAGE)

Institute for Basic Science

Figure 2

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Experimental data of this study. A) Injection of NYX-783 before the extinction therapy resulted in the successful extinction of PTSD memories and prevented spontaneous recovery. The drug treatment was more effective in female mice, suggesting differential sensitivity of NMDAR modulators in males and females. B) When the activity of endogenous BDNF was blocked in the mouse brain using an antibody, the PTSD memory underwent spontaneous recovery even after successful extinction. When the activity of endogenous BDNF was blocked, NYX-783 injected mice fared no better than those injected with saline.

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