Factors Increase Blood Supply to Breast Tumors (IMAGE)

NYU Langone Health / NYU Grossman School of Medicine

Factors Increase Blood Supply to Breast Tumors

Caption

These photomicrographs from mice show the significant difference in tumor vasculature (blood vessels) as a result of the increased expression of two factors (eIF4G and 4E-BP1) in locally advanced breast cancer. The vessels are stained with a fluorescent dye. The tumor on the right overexpresses the factors. Its vessels are much larger, irregularly shaped, extensive and leaky compared to the vasculature of tumors that do not overexpress the factors (left). The increased vascularization is thought to enable the much larger growth of locally advanced breast cancers

Credit

Robert J. Schneider

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