Force-rest changes (IMAGE) University of Kansas Caption Group differences in task-dependent right Crus I connectivity. A) Connectivity between right Crus I and a cluster in extrastriate cortex increased during force relative to rest in controls but decreased during force relative to rest in FMR1 premutation carriers. Blue indicates a larger force - rest interaction in controls compared to premutation carriers. Orange indicates a larger force-rest change in premutation carriers. Whole-brain effects are displayed, and a significant cluster in extrastriate cortex is outlined in black (voxel p < .005, cluster α < .03). B) Right Crus I seed region. C) Beta weights for force and rest PPI regressors were estimated using a leave-one-subject-out method. Error bars represent the mean and bootstrap estimated +/- 1 standard error. Credit McKinney, et al. Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.