Human embryo development without OCT4 (VIDEO) The Francis Crick Institute This video is under embargo. Please login to access this video. Caption This is a time lapse video showing human embryo development in embryos that have been edited so they do not produce the OCT4 protein. These embryos fail to form a stable blastocyst, showing that OCT4 is essential for blastocyst development. Credit Dr Kathy Niakan/Nature Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.