Rev-erb-alpha Pathway (IMAGE) University of Pennsylvania School of Medicine Caption The rev-erb-alpha/PGC1-alpha pathway regulating heme homeostasis. Credit Mitchell Lazar, M.D., Ph.D., University of Pennsylvania School of Medicine Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.