Great Dane (IMAGE) Michigan State University Caption Canine bloat is the No. 1 killer of Great Danes; large and deep-chested dogs are most prone to bloat. A Michigan State University research project will attempt to pinpoint the causes of the mysterious condition. Credit Tom Gennara Photography Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.