Artist's concept of launching the cellular DNA-damage response by the ATR-ATRIP complex (IMAGE)

University of Science and Technology of China

Artist's concept of launching the cellular DNA-damage response by the ATR-ATRIP complex

Caption

Despite constant assaults by endogenous and environmental agents on the DNA, the genomes are maintained by the elaborate mechanisms. As a master regulator of genomic stability, the ATR kinase (yellow helmet) acts together with its partner ATRIP protein (orange helmet) , forming a dimer of heterodimers and mobilizing a multitude of proteins (tools on the ground) to trigger one of the most extensive signaling cascade.

Credit

@University of Science and Technology of China, Illustration: Guoyan Wang and Lei Chen, University of Science & Technology of China

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