Fig.2 (IMAGE)

Osaka University

Fig.2

Caption

ADAR1 p150 Z-RNA binding domain (ZBD) mutated knock-in (KI) mice display severe growth retardation accompanied by Aicardi–Goutières syndrome (AGS)-like encephalopathy. Representative images of hematoxylin and eosin staining of brains show an enlarged lateral ventricle (*) and white matter vacuolation (arrow) in ZBD-mutated KI mice. The expression levels of interferon-stimulated genes (Ifit1 mRNA is shown as a representative gene) are increased, especially in the brain, in mutant mice. These abnormalities were ameliorated by concurrent deletion of MDA5 (MDA5 KO).

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Taisuke Nakahama et al.

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