Blocking the Cation Transport Pathway by P-CAB (IMAGE)

Nagoya University

Blocking the Cation Transport Pathway by P-CAB

Caption

The gastric proton pump export H+ into the gastric lumen, which follows uptake of K+ into the cytoplasm. Left panel shows slices of the transmembrane domain of the gastric proton pump. In the present structure, P-CAB (vonoprazan, magenta) binds in the middle of cation transport pathway (conduit), which blocks cation transport. The enlarged view of vonoprazan (magenta) binding site reveals its tight binding to the protein (right).

Credit

Kazuhiro Abe

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