Figure 2 Type 3 Receptor (5HT3R) (IMAGE)

Osaka University

Figure 2 Type 3 Receptor (5HT3R)

Caption

Our histological analysis reveals that serotonin type 3 receptor (5HT3R) and insulin-like growth factor 1 (IGF1) are expressed in the same neurons in the subgranular zone of the hippocampal dentate gyrus. Furthermore, we show that 5HT3R agonist treatment increases hippocampal extracellular IGF1 levels, and that 5HT3R-dependent hippocampal neurogenesis is mediated by IGF1 signaling. In addition, we also show that 5HT3R agonist induces antidepressant effects as well as hippocampal neurogenesis independent of SSRIs. Altogether, our findings suggest a novel 5HT3R-IGF1 mechanism that is distinct from SSRI-induced responses and that provides a new therapeutic target for depression, especially bringing significant benefits for SSRI-resistant depressed patients.

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Makoto Kondo

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