Memories are Stored for the Long-Term with the Help of Prion-Like Proteins Called CPEB (IMAGE)

Columbia University Irving Medical Center

Memories are Stored for the Long-Term with the Help of Prion-Like Proteins Called CPEB

Caption

Memories are stored for the long-term with the help of prion-like proteins called CPEB. CPEB prions aggregate and maintain synapses that recorded the memory ["spines" in the bottom image]. When CPEB prions are not present or are inactivated, the synapses collapse and the memory fades [see upper image].

Credit

Lab of David Sulzer, Ph.D., Columbia University Medical Center

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