Calpain inhibitor XII (IMAGE)

University of South Florida (USF Health)

Calpain inhibitor XII

Caption

X-ray crystal structure of the SARS-CoV-2 main protease interacting with calpain inhibitor XII (blue). The antiviral compound was shown to adopt an atypical configuration, called an inverted binding pose, to fit tightly into the targeted viral protein binding site.

Credit

Image generated by Michael Sacco of USF Health, using X-ray crystallography.

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