Comparison (IMAGE) Michigan Medicine - University of Michigan Caption These two microscope images give a close-up view of the inner part of human intestinal organoids grown from stem cells. The one on the left has formed a layer of cells to line the hollow center of the HIO, with the cell nuclei visible in blue. But the one on the right has developed even further, just 48 hours after E. coli was injected into the center of the HIO. The cells of the lining are using their genes to produce proteins and carbohydrates that show up in different colors, and make up the cell-to-cell connections and mucus layer that protect cells from invading microbes. Credit University of Michigan Usage Restrictions Credit University of Michigan License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.