Fig.3. Mechanism How the Laminin Isoforms Determine hiPS Cell Status and Fate (IMAGE)

Osaka University

Fig.3. Mechanism How the Laminin Isoforms Determine hiPS Cell Status and Fate

Caption

The binding affinity of substrates and integrins determines the nature of expanded hiPS cell colonies in terms of cell motility, cell-cell interactions, and cell density, with the clear involvement of Wnt and YAP signals. The respective immunohistochemical distributions of these laminin isoforms in the developing mouse eye mirrored hiPS cell type that was induced in vitro.

Credit

©2018 Shibata et al., <i>Cell Reports</i> 25, 1668-1679, doi: 10.1016/j.celrep.2018.10.032

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.