Chemo + Inhibitor Thwarts Potential Metastasis (IMAGE)

Southern Methodist University

Chemo + Inhibitor Thwarts Potential Metastasis

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Part A of Figure 4 shows that cells treated with a combination of chemo and inhibitor were thwarted in the process of metastasis -- a deadly challenge in the treatment of cancer. The researchers grew two-dimensional advanced cancer cells on cell plates, then used a pipette to scratch across each layer of cells to create a gap. Some of the cells were not treated (DMSO), some were treated with chemo (VIN), some with inhibitor (29, 34 and 45), and some with both (29+VIN, 34+VIN and 45+VIN). After 14 hours, those untreated and those treated with only chemo or only inhibitor, had proceeded toward closing the gap, indicating the chemo couldn't penetrate the cells, so those cancers could successfully metastasize. Those treated with a combination of chemo and inhibitor, were thwarted from migrating, indicating that the combination of the two drugs killed the cells and stopped migration and therefore metastasis. (Credit: SMU)

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