Schematic Model of PUM2 Impact on Age-related Mitochondrial Function (IMAGE)

Ecole Polytechnique Fédérale de Lausanne

Schematic Model of PUM2 Impact on Age-related Mitochondrial Function

Caption

Schematic model of PUM2 impact on age-related mitochondrial function. PUM2 expression increases upon aging and this facilitates the capture/trapping of Mff mRNA, either alone or in association with other RNA-binding proteins (RBPs) in Ribonucleoprotein particles (RNP). Consequently, PUM2 prevents Mff translation, impairing mitochondrial fission and mitophagy thereby leading to mitochondrial dysfunction.

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Davide D'Amico

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