Activation of Synaptic Plasticity (IMAGE)
Caption
Activation of synaptic plasticity: Schematic of proposed synaptic organization and events. Synchronous fusion begins within hundreds of microseconds near the AMPA receptors. Released glutamate activates AMPA receptors, which in turn depolarizes the membrane. Between 5 and 11 ms, residual calcium triggers asynchronous fusion, preferentially toward the center of the active zone and across from the NMDA receptors, favoring the NMDA receptor activation. This organization allows the maximal depolarization of the postsynaptic membrane and efficient activation of NMDA receptors - the switch for the plasticity.
Credit
Shuo Li et al., Nature Comm., 2021
Usage Restrictions
Please use with proper credit.
License
Licensed content