Autophagosome formation (IMAGE)

Japan Science and Technology Agency

Autophagosome formation

Caption

Isolation membranes expand to form autophagosomes by receiving lipids from endoplasmic reticulum, which is mediated by Atg2. However, Atg2 alone cannot mediate membrane expansion because lipids will accumulate at the cytoplasmic leaflet.

Credit

Nobuo N. Noda & Kazuaki Matoba

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