Japanese Scientists report the first enantioselective Pictet–Spengler reaction of acyclic α-ketoesters with tryptamines Clockwise from bottom left (IMAGE)

Nagoya Institute of Technology

Japanese Scientists report the first enantioselective Pictet–Spengler reaction of acyclic α-ketoesters with tryptamines Clockwise from bottom left

Caption

(1) Various pharmaceutical products containing biologically active chiral tetrahydro-β-carbolines (2) The proposed method using a chiral catalyst and the α-ketoester reactant (3) The transition state before the formation of the final enantioselective product

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Image courtesy: Shuichi Nakamura from NITech

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